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Sunday sees the first Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or the Magpies?
"For most of last season, you couldn't have imagined Sunderland getting promoted and being competitive with Eddie Howe's Newcastle, much less being above them in the table," commented pundit Chris Sutton.
"It is very different now, and the way they play leads me to believe they've got a solid shot."
He is offering predictions for all 380 Premier League games this season, against artificial intelligence, readers and a assortment of guests.
For this weekend's fixtures, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the England's esports team – the Football Association's formal esports team – at the EA Sports FC European esports championship finals tournament, which will occur at Twickenham Stadium on Saturday.
Viewers can catch Uefa's YouTube, Instagram Live and short-form video channels, as well as EA Sports FC Twitch and its YouTube counterpart and the national team's Twitch.
Are you in alignment with their scores? Feel free to submit your own guesses below.
The most popular scoreline chosen for each game is featured in the leaderboards at the foot of this page.
Predicting the right outcome (choosing a win, draw or defeat) is worth ten points. A perfect prediction earns 40 points.
Ray, who also plays his club side and the Premier League champions as well as England, is making his debut at the eEuros finals after successfully navigating the qualification rounds.
The final eight competitors will play for their countries at the finals in a single-elimination, competing for a six-figure prize fund and a prestigious spot in the FC Pro World Championship Play-Ins, with Denmark's Anders Vejrgang looking to retain the title he won last year.
"My mindset is really good for it," Ray stated. "I've got a really good coach with me and practice has been going well.
"Representing your country is always an honour to play for your country. Naturally when you are younger, you dream about doing it as an actual footballer, but when you go into this profession and there is an chance to represent England, putting the shirt on is something unique.
"I defeated Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"For me he is the top competitor in the world so defeating him in a tournament like this just provides a huge surge of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were excellent against Arsenal at the end of November, when they secured a point after going down to 10 men, and it seemed this is it, they could possibly be challengers for the crown.
However, since that game, however, they were overpowered by Leeds, looked flat against Bournemouth and this week got beaten by Atalanta in the Champions League.
So manager Enzo Maresca is in need of a win here to return to winning ways, but it won't be easy because the Toffees are such a potent team.
Two of their stars are playing exceptionally and Everton have got a bit of momentum at the moment.
On form you would likely back the visitors, while the most prudent prediction would probably be a draw, but I'm throwing caution to the wind.
They have not given me any compelling evidence to back them recently, but I just have a feeling Chelsea will emerge victorious because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be interesting to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot shouldn't need to put up with that nonsense. I know Salah has been a great for the club but at its core Slot just wants to win games and there is nothing personal in his team selection.
Liverpool changed their formation against Inter and went with a midfield diamond formation and two up top.
Everyone is going to be talking about whether Salah is included for this game, but the only way he is going to be reintegrated is if he apologises.
Slot's attention will be on winning this game, but it is a difficult fixture.
You could argue it is the same for most teams but I find Brighton so unpredictable. I always feel they have got a goal in them, but they are quite open too.
Liverpool need to get back to a consistent run of form, but I am not sure how much their exertions at the San Siro will have affected their stamina.
I have whacked a couple of Brighton players in my FPL team, so they will almost certainly blank - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the opportunity to rest while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
With the exception of their superb performance against Everton a couple of weeks ago, Newcastle's away form has been poor, particularly straight after they've played in the Champions League.
It is anticipated that that tendency to continue on Sunday, and their lack of freshness is likely to be a key element in how this game goes because of Sunderland's energetic style.
We saw how relentless Regis le Bris's side are. They bullied the Gunners, and it was amazing to watch.
Everyone talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays in midfield with him, has also been one of the top transfers and warrants praise too.
All signs point to this being the best game|most exciting fixture